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FDA APPROVES NEW INDICATION FOR PLAVIX (clopidogrel bisulfate) OFFERING NEW OPTION FOR PATIENTS

Sanofi-aventis and Bristol-Myers Squibb Company announced today that the U.S. Food and Drug Administration has approved the supplemental new drug application for the antiplatelet agent PLAVIX® (clopidogrel bisulfate) to reduce the rate of death from any cause and the rate of a combined endpoint of re-infarction, stroke or death in patients with acute ST-segment elevation myocardial infarction.

ADJUVANTED FORMULATION OF SANOFI PASTEUR H5N1 PANDEMIC INFLUENZA VACCINE CANDIDATE DEMONSTRATES SIGNIFICANT IMMUNE RESPONSE

Lyon, France – May 11, 2006 – A study published online in The Lancet on May 11 demonstrated that multiple dosage formulations of a candidate H5N1 influenza vaccine developed by sanofi pasteur were well-tolerated and generated an immune response, with and without adjuvant. Of the formulations being tested, an alum-adjuvanted 30 microgram (µg) dosage generated the most substantive immune response (

CHARISMA: NEW STUDY FURTHERS UNDERSTANDING OF THE ROLE OF DUAL ANTIPLATELET THERAPY IN THE PREVENTION OF ATHEROTHROMBOTIC EVENTS

Results from the CHARISMA trial showed that the combination of the antiplatelet agents clopidogrel and aspirin did not demonstrate a statistically significant reduction in the risk of heart attack, stroke or cardiovascular death compared to placebo and aspirin in a broad population of patients with either established atherothrombotic disease or multiple risk factors for atherothrombotic events.

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