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FDA GRANTS PRIORITY REVIEW TO PLAVIXÒ (clopidogrel bisulfate) SUPPLEMENTAL NEW DRUG APPLICATION (sNDA) FOR ADDITIONAL TYPE OF HEART ATTACK

Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and Bristol-Myers Squibb Company (NYSE: BMY) announced today that the U.S. Food and Drug Administration (FDA) has accepted for review a supplemental new drug application (sNDA) for the antiplatelet agent PLAVIX® (clopidogrel bisulfate) for treatment of patients with acute STsegment elevation myocardial infarction (STEMI).

SANOFI PASTEUR ANNOUNCES PRELIMINARY TRIAL RESULTS FOR A FIRST H5N1 PRE-PANDEMIC INFLUENZA VACCINE CANDIDATE WITH AN ADJUVANT

Vice President Communications sanofi pasteur: Alain BERNAL – U. S. Media Relations: Len LAVENDA Tel.: +1 570 839 7187 - Fax: +1 570 839 0955 - Sanofi Pasteur Inc. - Discovery Drive - Swiftwater, PA 18370-0187 - USA - www.sanofipasteur.com ~ Data Show that the Vaccine Is Safe, Demonstrates Immunogenicity and Provides Future Direction For Development ~ Lyon, France – December 15, 2005 – Sano

INTERIM ANALYSIS OF PHASE III STUDY SHOWS TAXOTERE®-BASED REGIMENS WITH HERCEPTIN® SIGNIFICANTLY IMPROVED DISEASE FREE SURVIVAL IN WOMEN WITH EARLY-STAGE HER2-POSITIVE BREAST CANCER

Results from the BCIRG 006 study also show that a novel non-anthracycline-based regimen (“TCH”) with TAXOTERE® (docetaxel), the platinum salt carboplatin and HERCEPTIN® (trastuzumab) reduces the risk of recurrence without increasing cardiotoxicity in patients with early stage HER2-positive breast cancer Paris and San Antonio – December 8th, 2005 – The Breast Cancer International Research Group

FDA GRANTS PRIORITY REVIEW TO TAXOTERE FOR THE SUPPLEMENTAL NEW DRUG APPLICATION FOR ADVANCED GASTRIC CANCER

Paris – December 2, 2005 – Sanofi-aventis announced today that the U.S Food and Drug Administration (FDA) has granted a six-month priority review for the supplemental new drug application (s-NDA) for Taxotere (docetaxel) Injection Concentrate, in combination with a current standard treatment (cisplatin and 5-fluorouracil) for advanced gastric cancer. The supplemental application is based on d

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